Hypoxia imaging and adaptive radiotherapy: a state-of-the-art approach in the management of glioma

M Gérard, A Corroyer-Dulmont, P Lesueur… - Frontiers in …, 2019 - frontiersin.org
Severe hypoxia [oxygen partial pressure (pO2) below 5–10 mmHg] is more frequent in
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the …

Cerebrovascular heterogeneity and neuronal excitability

L Librizzi, M de Cutis, D Janigro, L Runtz, F de Bock… - Neuroscience …, 2018 - Elsevier
The cerebral vasculature is a complex tridimensional network of arterial and venous vessels
which are anatomically in proximity of and functionally coupled to neurons. Depending on …

A novel integrated system using patient-derived glioma cerebral organoids and xenografts for disease modeling and drug screening

L Zhang, F Liu, N Weygant, J Zhang, P Hu, Z Qin… - Cancer Letters, 2021 - Elsevier
A physiologically relevant glioma tumor model is important to the study of disease
progression and screening drug candidates. However, current preclinical glioma models …

Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy

A Corroyer-Dulmont, S Valable, J Fantin, L Chatre… - Scientific Reports, 2021 - nature.com
Lung cancer patients frequently develop brain metastases (BM). Despite aggressive
treatment including neurosurgery and external-radiotherapy, overall survival remains poor …

Nanosized zeolites as a gas delivery platform in a glioblastoma model

C Anfray, S Komaty, A Corroyer-Dulmont, M Zaarour… - Biomaterials, 2020 - Elsevier
Approaches able to counteract, at least temporarily, hypoxia, a well-known factor of
resistance to treatment in solid tumors are highly desirable. Herein, we report the use of …

The extension of the LeiCNS-PK3. 0 model in combination with the “Handshake” approach to understand brain tumor pathophysiology

M Hirasawa, MAA Saleh, ECM de Lange - Pharmaceutical Research, 2022 - Springer
Micrometastatic brain tumor cells, which cause recurrence of malignant brain tumors, are
often protected by the intact blood–brain barrier (BBB). Therefore, it is essential to deliver …

Gas Delivery Relevant to Human Health using Porous Materials

RM Mandel, PS Lotlikar, KT Keasler… - … A European Journal, 2024 - Wiley Online Library
Gases are essential for various applications relevant to human health, including in medicine,
biomedical imaging, and pharmaceutical synthesis. However, gases are significantly more …

Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults

PT Deckers, AA Bhogal… - Journal of Cerebral …, 2022 - journals.sagepub.com
Blood oxygenation level-dependent (BOLD) or arterial spin labeling (ASL) MRI with
hypercapnic stimuli allow for measuring cerebrovascular reactivity (CVR). Hypercapnic …

Prolonged hyperoxygenation treatment improves vein graft patency and decreases macrophage content in atherosclerotic lesions in ApoE3* Leiden mice

L Parma, HAB Peters, F Baganha, JC Sluimer… - Cells, 2020 - mdpi.com
Unstable atherosclerotic plaques frequently show plaque angiogenesis which increases the
chance of rupture and thrombus formation leading to infarctions. Hypoxia plays a role in …

Functional impact of oxygen-saturated zeolite nanoparticles on macrophages in the context of glioblastoma: an in vitro and in vivo study

FE Aurélie, K Sarah, H Charly, A Clément… - Colloids and Surfaces B …, 2023 - Elsevier
In the context of glioblastoma (GBM), hypoxia and inflammation are two main players of the
tumor microenvironment. Hypoxia stimulates various features involves in tumor growth and …