Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in
various physiological activities of the ovary through signaling and are critical for regulating …

Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate
endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role …

Melatonin is a natural indoleamine produced by the pineal gland that has many functions,
including regulation of the circadian rhythm. Many studies have reported the anticancer …

Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …

Cancer is a large group of diseases and the second leading cause of death worldwide.
Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer …

Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …

Cancers are serious life-threatening diseases which annually are responsible for millions of
deaths across the world. Despite many developments in therapeutic approaches for affected …

The tumor microenvironment (TME) includes a number of non-cancerous cells that affect
cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress …

Immune system interactions within the tumour have a key role in the resistance or
sensitization of cancer cells to anti-cancer agents. On the other hand, activation of the …

There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the
production of testosterone. Increasing evidence shows that melatonin benefits the …