Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Heavy metal toxicity has become a pressing ecological problem that affects the ecosystems
through bioaccumulation, representing a serious public health hazard. Many conventional …

Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

The Klebsiella group, found in humans, livestock, plants, soil, water and wild animals, is
genetically and ecologically diverse. Many species are opportunistic pathogens and can …

Polymyxins are last-resort antibiotics with potent activity against multi-drug resistant
pathogens. They interact with lipopolysaccharide (LPS) in bacterial membranes, but …

The emergence of multidrug-resistant (MDR) bacteria in recent years has been alarming
and represents a major public health problem. The development of effective antimicrobial …

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing
problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) …

ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

Bacterial infections are one of the leading causes of death worldwide. In the case of topical
bacterial infections such as wound infections, silver (Ag) has historically been one of the …

The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …