Amyotrophic lateral sclerosis: translating genetic discoveries into therapies
Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …
Brain metabolism in health, aging, and neurodegeneration
S Camandola, MP Mattson - The EMBO journal, 2017 - embopress.org
Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing
activity in neuronal circuits, and from environmental energetic stressors such as food …
activity in neuronal circuits, and from environmental energetic stressors such as food …
ESPEN guideline clinical nutrition in neurology
Neurological diseases are frequently associated with swallowing disorders and malnutrition.
Moreover, patients with neurological diseases are at increased risk of micronutrient …
Moreover, patients with neurological diseases are at increased risk of micronutrient …
[HTML][HTML] Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease
TJ Tracey, FJ Steyn, EJ Wolvetang… - Frontiers in molecular …, 2018 - frontiersin.org
Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …
processes related to their structural diversity, and based on this can be broadly classified …
Energy metabolism in ALS: an underappreciated opportunity?
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …
Prognostic factors in ALS: a critical review
We have performed a systematic review to summarize current knowledge concerning factors
related to survival in ALS and to evaluate the implications of these data for clinical trials …
related to survival in ALS and to evaluate the implications of these data for clinical trials …
Effect of high‐caloric nutrition on survival in amyotrophic lateral sclerosis
AC Ludolph, J Dorst, J Dreyhaupt… - Annals of …, 2020 - Wiley Online Library
Objective Weight loss has been identified as a negative prognostic factor in amyotrophic
lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases …
lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases …
Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis
MD Wang, J Little, J Gomes, NR Cashman, D Krewski - Neurotoxicology, 2017 - Elsevier
Although amyotrophic lateral sclerosis (ALS) was identified as a neurological condition 150
years ago, risk factors related to the onset and progression of ALS remain largely unknown …
years ago, risk factors related to the onset and progression of ALS remain largely unknown …
Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism
BA Golomb, MA Evans - American Journal of Cardiovascular Drugs, 2008 - Springer
HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …
Energy metabolism in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is characterised by the progressive degeneration of
upper and lower motor neurons. Besides motor neuron degeneration, ALS is associated …
upper and lower motor neurons. Besides motor neuron degeneration, ALS is associated …