Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

With only a fraction of patients responding to cancer immunotherapy, a better understanding
of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart …

Abstract Purpose: Cancer-associated fibroblasts (CAFs) are an important component of the
tumor microenvironment, but a systematic investigation of their molecular characteristics and …

CD19-directed immunotherapies are clinically effective for treating B cell malignancies but
also cause a high incidence of neurotoxicity. A subset of patients treated with chimeric …

INTRODUCTION Dendritic cells (DCs) and monocytes consist of multiple specialized
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

Chimeric antigen receptor T cells (CAR-T cells) have emerged as a powerful treatment
option for individuals with B cell malignancies but have yet to achieve success in treating …