The mitochondrial permeability transition pore (MPTP) is a non-specific pore that opens in
the inner mitochondrial membrane (IMM) when matrix [Ca 2+] is high, especially when …

Mitochondria have emerged as key participants in and regulators of myocardial injury during
ischemia and reperfusion. This review examines the sites of damage to cardiac …

The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS)
under pathological conditions including myocardial ischemia and reperfusion. Limitation of …

Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

Cytochrome c oxidase (CcO) is the terminal oxidase of the mitochondrial electron transport
chain. This bigenomic enzyme in mammals contains 13 subunits of which the 3 catalytic …

There remains an unmet need to identify novel therapeutic strategies capable of protecting
the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to …

Mitochondria contribute to cardiac dysfunction and myocyte injury via a loss of metabolic
capacity and by the production and release of toxic products. This article discusses aspects …

Cardiovascular disease (CVD) is a key cause of deaths worldwide, comprising 15–17% of
healthcare expenditure in developed countries. Current records estimate an annual global …

Mitochondria play a key role in determining cell fate during exposure to stress. Their role
during ischemia/reperfusion is particularly critical because of the conditions that promote …