The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

In living tissues, cells express their functions following complex signals from their
surrounding microenvironment. Capturing both hierarchical architectures at the micro‐and …

Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …

Gene expression is tightly regulated, with many genes exhibiting cell-specific silencing
when their protein product would disrupt normal cellular function. This silencing is largely …

Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic
precursor cells derived from human embryonic stem cells found that insulin output was …

Population-level variation and mechanisms behind insulin secretion in response to
carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin …