Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Liquid-liquid phase separation of α-synuclein: a new mechanistic insight for α-synuclein aggregation associated with Parkinson's disease pathogenesis
Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
Wetting and complex remodeling of membranes by biomolecular condensates
Cells compartmentalize parts of their interiors into liquid-like condensates, which can be
reconstituted in vitro. Although these condensates interact with membrane-bound …
reconstituted in vitro. Although these condensates interact with membrane-bound …
Mass photometric detection and quantification of nanoscale α-synuclein phase separation
S Ray, TO Mason, L Boyens-Thiele, A Farzadfard… - Nature …, 2023 - nature.com
Protein liquid–liquid phase separation can lead to disease-related amyloid fibril formation.
The mechanisms of conversion of monomeric protein into condensate droplets and of the …
The mechanisms of conversion of monomeric protein into condensate droplets and of the …
Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates
SK Rai, R Khanna, A Avni… - Proceedings of the …, 2023 - National Acad Sciences
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …
Biomolecular condensates modulate membrane lipid packing and hydration
Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in
cell biology, playing an important role in a diverse range of processes across different …
cell biology, playing an important role in a diverse range of processes across different …
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid
LD Aubrey, N Ninkina, SM Ulamec… - Proceedings of the …, 2024 - National Acad Sciences
α-, β-, and γ-Synuclein are intrinsically disordered proteins implicated in physiological
processes in the nervous system of vertebrates. α-synuclein (αSyn) is the amyloidogenic …
processes in the nervous system of vertebrates. α-synuclein (αSyn) is the amyloidogenic …
The bacterial nucleoid-associated proteins, HU and Dps, condense DNA into context-dependent biphasic or multiphasic complex coacervates
The bacterial chromosome, known as its nucleoid, is an amorphous assemblage of globular
nucleoprotein domains. It exists in a state of phase separation from the cell's cytoplasm, as …
nucleoprotein domains. It exists in a state of phase separation from the cell's cytoplasm, as …