Protein aggregation–mechanisms, detection, and control
W Wang, CJ Roberts - International journal of pharmaceutics, 2018 - Elsevier
Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …
development and commercialization of successful protein-based drug products because of …
[HTML][HTML] Antibody stability: A key to performance-Analysis, influences and improvement
H Ma, C Ó'Fágáin, R O'Kennedy - Biochimie, 2020 - Elsevier
An antibody's stability greatly influences its performance (ie its specificity and affinity). Thus,
stability is a major issue for researchers and manufacturers, especially with the increasing …
stability is a major issue for researchers and manufacturers, especially with the increasing …
An evaluation of the delivery of medicines using drones
MSY Hii, P Courtney, PG Royall - Drones, 2019 - mdpi.com
This study tests the impact of drone transportation on the quality of a medicine. Modelling the
critical process parameters of drone flight, the effects of temperature and vibration on insulin …
critical process parameters of drone flight, the effects of temperature and vibration on insulin …
Label-free detection of tear biomarkers using hydrogel-coated gold nanoshells in a localized surface plasmon resonance-based biosensor
HR Culver, ME Wechsler, NA Peppas - ACS nano, 2018 - ACS Publications
The dependence of the localized surface plasmon resonance (LSPR) of noble-metal
nanomaterials on refractive index makes LSPR a useful, label-free signal transduction …
nanomaterials on refractive index makes LSPR a useful, label-free signal transduction …
Science and art of protein formulation development
W Wang, S Ohtake - International journal of pharmaceutics, 2019 - Elsevier
Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …
expected to grow steadily over the next decade. Development of a commercial protein …
Forced degradation studies of biopharmaceuticals: Selection of stress conditions
Stability studies under stress conditions or forced degradation studies play an important role
in different phases of development and production of biopharmaceuticals and biological …
in different phases of development and production of biopharmaceuticals and biological …
Environmental factors modulating protein conformations and their role in protein aggregation diseases
The adverse physiological conditions have been long known to impact protein synthesis,
folding and functionality. Major physiological factors such as the effect of pH, temperature …
folding and functionality. Major physiological factors such as the effect of pH, temperature …
Impact of buffer, protein concentration and sucrose addition on the aggregation and particle formation during freezing and thawing
A Hauptmann, K Podgoršek, D Kuzman, S Srčič… - Pharmaceutical …, 2018 - Springer
Purpose This study addresses the effect of freezing and thawing on a therapeutic
monoclonal antibody (mAb) solution and the corresponding buffer formulation. Particle …
monoclonal antibody (mAb) solution and the corresponding buffer formulation. Particle …
[HTML][HTML] Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics
In antibody development and manufacturing, protein aggregation is a common challenge
that can lead to serious efficacy and safety issues. To mitigate this problem, it is important to …
that can lead to serious efficacy and safety issues. To mitigate this problem, it is important to …
Electrostatic and covalent assemblies of anionic hydrogel-coated gold nanoshells for detection of dry eye biomarkers in human tears
ME Wechsler, HKH Jocelyn Dang, SP Simmonds… - Nano …, 2021 - ACS Publications
Although dry eye is highly prevalent, many challenges exist in diagnosing the symptom and
related diseases. For this reason, anionic hydrogel-coated gold nanoshells (AuNSs) were …
related diseases. For this reason, anionic hydrogel-coated gold nanoshells (AuNSs) were …