In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of
blood flow in a certain part of the brain, leading to serious disability and death. At present …

Endoplasmic reticulum (ER) is the main organelle for protein synthesis, trafficking and
maintaining intracellular Ca2+ homeostasis. The stress response of ER results from the …

A lack of the trace element zinc (Zn) in freshwater environments causes slow growth and
malnutrition and affects the normal biological functions of organisms. In this study, a Zn …

The endoplasmic reticulum (ER) is a cellular organelle that is physiologically responsible for
protein folding, calcium homeostasis, and lipid biosynthesis. Pathological stimuli such as …

With the purpose to explore the mechanisms associated with the intestinal toxicity of
Ochratoxin A (OTA), an intestinal porcine epithelial cell line (IPEC-J2) was applied in this …

We have previously shown that biochanin A exhibits neuroprotective properties in the
context of cerebral ischemia/reperfusion (I/R) injury. The mechanistic basis for such …

This study was conducted to explore the beneficial role of taurine against chronic high
carbohydrate diet-induced oxidative stress, endoplasmic reticulum (ER) stress and …

Recent reports considered that it was the disturbance of calcium homeostasis and the
accumulation of misfolded proteins in the endoplasmic reticulum (ER) that activated hepatic …

Silver nanoparticles (AgNPs) have many medical and commercial applications, but their
effects on human health are poorly understood. The aim of this study was to assess the …