Protein fusion using a linker plays an important role for protein evolution. However,
designing suitable linkers for protein evolution is yet challenging and under-explored. To …

Sardinia is a major Island in the Mediterranean with a high incidence of multiple sclerosis, a
chronic autoimmune inflammatory disease of the central nervous system. Disease …

The present work focuses on the dynamical aspects of cross-reactivity between myelin
based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy. 1B11 T …

TRF2 is a telomere binding protein, a component of the shelterin complex that plays a major
role in maintaining the integrity of the genome. TRF2 is over-expressed in a number of …

The emergence of bacterial multidrug resistance is an increasing problem in treatment of
infectious diseases. An important cause for the multidrug resistance of bacteria is the …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that has a
notably high incidence in Sardinia. Our study focuses on two HLA class II haplotypes …

In the exchange of metabolites and ions between the mitochondrion and the cytosol, the
voltage-dependent anion channel (VDAC) is a key element, as it forms the major transport …

Commensal and pathogenic enteric bacteria have developed several systems to adapt to
proton leakage into the cytoplasm resulting from extreme acidic conditions. One such system …

The µ opioid receptor (µ OR), the principal target to control pain, belongs to the G protein-
coupled receptors (GPCRs) family, one of the most highlighted protein families due to their …

The drive towards organic computing is gaining momentum. Interestingly, the building
blocks for such architectures is based on molecular ensembles extending from nucleic acids …