The physical frailty syndrome as a transition from homeostatic symphony to cacophony

LP Fried, AA Cohen, QL Xue, J Walston… - Nature aging, 2021 - nature.com
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

[HTML][HTML] Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review

J Apóstolo, R Cooke, E Bobrowicz-Campos… - JBI Evidence …, 2018 - journals.lww.com
Objective: To summarize the best available evidence regarding the effectiveness of
interventions for preventing frailty progression in older adults. Introduction: Frailty is an age …

Delaying and reversing frailty: a systematic review of primary care interventions

J Travers, R Romero-Ortuno, J Bailey… - British Journal of General …, 2019 - bjgp.org
Background Recommendations for routine frailty screening in general practice are
increasing as frailty prevalence grows. In England, frailty identification became a contractual …

Differences in handgrip strength protocols to identify sarcopenia and frailty-a systematic review

AR Sousa-Santos, TF Amaral - BMC geriatrics, 2017 - Springer
Background Hand grip strength (HGS) is used for the diagnosis of sarcopenia and frailty.
Several factors have been shown to influence HGS values during measurement. Therefore …

Current and emerging biomarkers of frailty in the elderly

AA Saedi, J Feehan, S Phu, G Duque - Clinical interventions in …, 2019 - Taylor & Francis
The term “frailty” is used to describe a subset of older adults who appear weaker and more
vulnerable than their age-matched counterparts, despite having similar comorbidities …

Hypogonadism and male obesity: focus on unresolved questions

M Grossmann - Clinical Endocrinology, 2018 - Wiley Online Library
Obesity, increasing in prevalence globally, is the clinical condition most strongly associated
with lowered testosterone concentrations in men and presents as one of the strongest …

Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: a meta-analysis

SHF Macdonald, J Travers, EN She, J Bailey… - PLoS …, 2020 - journals.plos.org
Introduction The best interventions to address frailty among older adults have not yet been
fully defined, and the diversity of interventions and outcome measures makes this process …

Therapeutic interventions for frail elderly patients: part I. Published randomized trials

L Bibas, M Levi, M Bendayan, L Mullie… - Progress in …, 2014 - Elsevier
The body of literature for frailty as a prognostic marker continues to grow, yet the evidence
for frailty as a therapeutic target is less well defined. In the setting of cardiovascular disease …

Aromatase inhibitors in men: effects and therapeutic options

W De Ronde, FH de Jong - Reproductive Biology and Endocrinology, 2011 - Springer
Aromatase inhibitors effectively delay epiphysial maturation in boys and improve
testosterone levels in adult men Therefore, aromatase inhibitors may be used to increase …

Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women

AM Kenny, RS Boxer, A Kleppinger… - Journal of the …, 2010 - Wiley Online Library
OBJECTIVES: To investigate the effects of dehydroepiandrosterone (DHEA) combined with
exercise on bone mass, strength, and physical function in older, frail women. DESIGN …