DNA-framework-based multidimensional molecular classifiers for cancer diagnosis
A molecular classification of diseases that accurately reflects clinical behaviour lays the
foundation of precision medicine. The development of in silico classifiers coupled with …
foundation of precision medicine. The development of in silico classifiers coupled with …
Shaping chromatin states in prostate cancer by pioneer transcription factors
The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …
MEIS transcription factors in development and disease
D Schulte, D Geerts - Development, 2019 - journals.biologists.com
ABSTRACT MEIS transcription factors are key regulators of embryonic development and
cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed …
cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed …
SOX2 mediates metabolic reprogramming of prostate cancer cells
New strategies are needed to predict and overcome metastatic progression and therapy
resistance in prostate cancer. One potential clinical target is the stem cell transcription factor …
resistance in prostate cancer. One potential clinical target is the stem cell transcription factor …
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer
Y Li, Y Gan, J Liu, J Li, Z Zhou, R Tian, R Sun… - Signal transduction and …, 2022 - nature.com
Oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), but an
estimated 50% of patients will eventually stop responding to treatment due to acquired …
estimated 50% of patients will eventually stop responding to treatment due to acquired …
Imaging fibroblast activation protein alpha improves diagnosis of metastatic prostate cancer with positron emission tomography
HM Hintz, JP Gallant, DJ Vander Griend… - Clinical Cancer …, 2020 - AACR
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) is a lethal, heterogeneous
disease with few therapeutic strategies that significantly prolong survival. Innovative …
disease with few therapeutic strategies that significantly prolong survival. Innovative …
HOXB13 promotes gastric cancer cell migration and invasion via IGF-1R upregulation and subsequent activation of PI3K/AKT/mTOR signaling pathway
C Guo, H Chu, Z Gong, B Zhang, C Li, J Chen, L Huang - Life Sciences, 2021 - Elsevier
Aims This study aimed at exploring HOXB13 expression and function in gastric cancer (GC),
and the underlying molecular mechanism. Materials and methods HOXB13 and fat mass …
and the underlying molecular mechanism. Materials and methods HOXB13 and fat mass …
Inhibition of Senescence‐Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post–Myocardial Infarction
Background Myocardial infarction results in a large‐scale cardiomyocyte loss and heart
failure due to subsequent pathological remodeling. Whereas zebrafish and neonatal mice …
failure due to subsequent pathological remodeling. Whereas zebrafish and neonatal mice …
Cancer cells retrace a stepwise differentiation program during malignant progression
S Saghafinia, K Homicsko, A Di Domenico… - Cancer discovery, 2021 - AACR
Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively
benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the …
benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the …
The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients
Background Recently, a novel HOXB13 variant (X285K) was observed in men of African
descent with prostate cancer (PCa) in Martinique. Little is known about this or other variants …
descent with prostate cancer (PCa) in Martinique. Little is known about this or other variants …