Fibrin mechanical properties and their structural origins

RI Litvinov, JW Weisel - Matrix Biology, 2017 - Elsevier
Fibrin is a protein polymer that is essential for hemostasis and thrombosis, wound healing,
and several other biological functions and pathological conditions that involve extracellular …

Advances in fibrin-based materials in wound repair: a review

IS Bayer - Molecules, 2022 - mdpi.com
The first bioprocess that occurs in response to wounding is the deterrence of local
hemorrhage. This is accomplished by platelet aggregation and initiation of the hemostasis …

Structural basis for the nonlinear mechanics of fibrin networks under compression

OV Kim, RI Litvinov, JW Weisel, MS Alber - Biomaterials, 2014 - Elsevier
Fibrin is a protein polymer that forms a 3D filamentous network, a major structural
component of protective physiological blood clots as well as life threatening pathological …

Characterization of strut indentation during mechanical thrombectomy in acute ischemic stroke clot analogs

FM Weafer, S Duffy, I Machado, G Gunning… - Journal of …, 2019 - jnis.bmj.com
Background Although it is common practice to wait for an 'embedding time'during
mechanical thrombectomy (MT) to allow strut integration of a stentriever device into an …

SOAX: a software for quantification of 3D biopolymer networks

T Xu, D Vavylonis, FC Tsai, GH Koenderink, W Nie… - Scientific reports, 2015 - nature.com
Filamentous biopolymer networks in cells and tissues are routinely imaged by confocal
microscopy. Image analysis methods enable quantitative study of the properties of these …

Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow

S Xu, Z Xu, OV Kim, RI Litvinov… - Journal of the …, 2017 - royalsocietypublishing.org
Thromboembolism, one of the leading causes of morbidity and mortality worldwide, is
characterized by formation of obstructive intravascular clots (thrombi) and their mechanical …

Nanomedical applications of nanoparticles for blood coagulation disorders

A Lateef, SA Ojo, JA Elegbede, PO Akinola… - Environmental …, 2018 - Springer
Nanotechnology has evolved as a novel multidisciplinary concept of the twenty-first century,
abridging gaps in materials science, engineering, life sciences and medicine, with …

Nonlinear, dissipative phenomena in whole blood clot mechanics

GP Sugerman, SH Parekh, MK Rausch - Soft Matter, 2020 - pubs.rsc.org
When a thrombus breaks off and embolizes it can occlude vital vessels such as those of the
heart, lung, or brain. These thromboembolic conditions are responsible for 1 in 4 deaths …

Elastic behavior and platelet retraction in low-and high-density fibrin gels

AR Wufsus, K Rana, A Brown, JR Dorgan… - Biophysical journal, 2015 - cell.com
Fibrin is a biopolymer that gives thrombi the mechanical strength to withstand the forces
imparted on them by blood flow. Importantly, fibrin is highly extensible, but strain hardens at …

[HTML][HTML] Fibrin-based bioinks: New tricks from an old dog

A Shpichka, D Osipova, Y Efremov… - … Journal of Bioprinting, 2020 - ncbi.nlm.nih.gov
For the past 10 years, the main efforts of most bioprinting research teams have focused on
creating new bioink formulations, rather than inventing new printing set-up concepts. New …