Nitric oxide (NO) is a gaseous signaling molecule that plays an important role in myriad
physiological processes including the regulation of vascular tone, neurotransmission …

The design of the energy metabolism system in striated muscle remains a major area of
investigation. Here, we review our current understanding and emerging hypotheses …

The physiological determinants of high-intensity exercise tolerance are important for both
elite human performance and morbidity, mortality and disease in clinical settings. The …

Abstract Resting humans transport~ 100 quintillion (1018) oxygen (O2) molecules every
second to tissues for consumption. The final, short distance (< 50 µm) from capillary to the …

Three sentinel parameters of aerobic performance are the maximal oxygen uptake (), critical
power (CP) and speed of the kinetics following exercise onset. Of these, the latter is …

August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism
(1906) and overturning the concept of active transport of gases across the pulmonary …

Hypoxia, defined as a reduced oxygen availability, can be observed in many tissues in
response to various physiological and pathological conditions. As a hallmark of the altitude …

Our aim is to present an updated overview of the erythrocyte metabolism highlighting its
richness and complexity. We have manually collected and connected the available …

Key points Dietary nitrate supplementation increases plasma nitrite concentration, which
provides an oxygen‐independent source of nitric oxide and can delay skeletal muscle …

The oxygen transport pathway from air to mitochondria involves a series of transfer steps
within closely integrated systems (pulmonary, cardiovascular, and tissue metabolic). Small …