The esophagus is derived from the anterior portion of the developmental intermediate
foregut, a structure that also gives rise to other organs including the trachea, lung, and …

Smooth muscle is increasingly recognized as a key mechanical sculptor of epithelia during
embryonic development. Smooth muscle is a mesenchymal tissue that surrounds the …

The existence and function of Lgr5+ cells within the developing esophagus remains
unknown. Here, we document multiple discrete Lgr5+ populations in the developing mouse …

The esophagus links the oral cavity to the stomach and facilitates the transfer of bolus. Using
genetic tracing and mouse mutants, we demonstrate that esophagus striated muscles …

The esophagus is derived from the anterior portion of the foregut endoderm, which also
gives rise to the respiratory system. As it develops, the esophageal lining is transformed from …

The gastrointestinal tract is an essential system of organs required for nutrient absorption. As
a simple tube early in development, the primitive gut is patterned along its anterior-posterior …

In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the
esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated …

The gastroesophageal junction has been of clinical interest for some time due to its
important role in preventing reflux of caustic stomach contents upward into the esophagus …

The human stomach functions as both a digestive and innate immune organ. Its main
product, acid, rapidly breaks down ingested products and equally serves as a highly …

The esophagus functions to transport food from the oropharyngeal region to the stomach via
waves of peristalsis and transient relaxation of the lower esophageal sphincter. The …