Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The development of more effective methods of relieving pain associated with burn injury is a
major unmet medical need. Not only is acute burn injury pain a source of immense suffering …

Background As in other fields of medicine, development of new medications for
management of neuropathic pain has been difficult since preclinical rodent models do not …

Evidence from the last several decades indicates that the excitatory amino acid glutamate
plays a significant role in nociceptive processing. Glutamate and glutamate receptors are …

Background Non-cardiac chest pain mimics angina pectoris but generally originates from
the oesophagus. Visceral hypersensitivity may contribute, but its neurophysiological basis is …

Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with
hyperalgesia and has been proposed to be a cellular mechanism of pain amplification in …

Hyperalgesia and allodynia following peripheral tissue or nerve injury are not only due to an
increase in the sensitivity of primary afferent nociceptors at the site of injury but also depend …

Background Pain localization is one of the hallmarks for the choice of first-line treatment in
neuropathic pain. This literature review has been conducted to provide an overview of the …

Evidence has accumulated that the N-methyl-d-aspartate receptor system plays a role in
continuous and particularly, in stimulus-evoked pain after nerve injury. We examined, in a …