The use of pharmacological chaperones in rare diseases caused by reduced protein stability

J Gil‐Martínez, G Bernardo‐Seisdedos, JM Mato… - …, 2022 - Wiley Online Library
Rare diseases are most often caused by inherited genetic disorders that, after translation,
will result in a protein with altered function. Decreased protein stability is the most frequent …

[HTML][HTML] On the potentially spurious contributions of cosolutes in protein 15N relaxation dispersion measurements

B Mateos, O Millet - Journal of Magnetic Resonance Open, 2022 - Elsevier
A rigorous quantification of the thermodynamics, kinetic and structural changes can be
approached by relaxation dispersion methods, when such motions are in the microsecond to …

On the effect of cosolutes and crowders in the stability and kinetic properties of proteins

N Zalba Olaizola - 2022 - addi.ehu.es
[EN] It is known since long time that life is present in every environment on Earth, however,
this fact results surprising, since some of such environments are characterized by conditions …