Immunoproteasomes contain replacements for the three catalytic subunits of standard
proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that …

Maintenance of protein homeostasis, also referred to as “Proteostasis”, integrates multiple
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …

Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but
accumulate with age and disease. We demonstrate the importance of various forms of the …

The proteasome is a large multi-subunit protease responsible for the degradation and
removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays …

The ability to adapt to acute oxidative stress (eg H 2 O 2, peroxynitrite, menadione, and
paraquat) through transient alterations in gene expression is an important component of …

During viral infection, proper regulation of immune responses is necessary to ensure
successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role …

Here, we review the role of oxidative protein modification as a signal for recognition and
degradation of proteins. It was clearly demonstrated that the ATP-and ubiquitin-independent …

The proteasome is the major protein degradation system within the cell, comprised of
different proteolytic subunits; amyloid-β is thought to impair its activity in Alzheimer's …

We report an entirely new role for the HSP70 chaperone in dissociating 26S proteasome
complexes (into free 20S proteasomes and bound 19S regulators), preserving 19S …

Cellular proteins are exposed to oxidative modification and other forms of damage through
oxidative stress and disease, and as a consequence of aging. This oxidative damage results …