The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …

Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …

The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Molecular knowledge of biological processes is a cornerstone in omics data analysis.
Applied to single‐cell data, such analyses provide mechanistic insights into individual cells …

Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Pathological aggregation of tau is a hallmark of Alzheimer's disease and related
tauopathies. We have previously shown that the deficiency of the microglial fractalkine …

The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple
signal transduction pathways, including three groups of mitogen-activated protein (MAP) …

The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs)
were first elucidated in 1994, and by 2001, substantial progress had been made in …

Following heat stress, the mammalian intestinal epithelial cells respond by producing heat
shock proteins that confer protection under stressful conditions, which would otherwise lead …