[HTML][HTML] Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
Haematopoietic and immune defects associated with GATA2 mutation
Heterozygous familial or sporadic GATA 2 mutations cause a multifaceted disorder,
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …
Candidate silencer elements for the human and mouse genomes
The study of gene regulation is dominated by a focus on the control of gene activation or
increase in the level of expression. Just as critical is the process of gene repression or …
increase in the level of expression. Just as critical is the process of gene repression or …
[PDF][PDF] Dynamic control of enhancer repertoires drives lineage and stage-specific transcription during hematopoiesis
Enhancers are the primary determinants of cell identity, but the regulatory components
controlling enhancer turnover during lineage commitment remain largely unknown. Here we …
controlling enhancer turnover during lineage commitment remain largely unknown. Here we …
[PDF][PDF] A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv (3)(q21; q26) by activating EVI1 expression
Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …
The GATA factor revolution in hematology
KR Katsumura, EH Bresnick… - Blood, The Journal …, 2017 - ashpublications.org
The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …
[HTML][HTML] Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity
KD Johnson, AP Hsu, MJ Ryu, J Wang… - The Journal of …, 2012 - Am Soc Clin Investig
The transcription factor GATA-2 plays vital roles in quite diverse developmental programs,
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified …
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified …
Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo
The generation of hematopoietic stem cells (HSCs) from hemogenic endothelium within the
aorta, gonad, mesonephros (AGM) region of the mammalian embryo is crucial for …
aorta, gonad, mesonephros (AGM) region of the mammalian embryo is crucial for …
[PDF][PDF] Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions
Summary Polycomb repressive complex 2 (PRC2) plays crucial roles in transcriptional
regulation and stem cell development. However, the context-specific functions associated …
regulation and stem cell development. However, the context-specific functions associated …
Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning
The transcription factor GATA-2 plays vital roles in quite diverse developmental programs,
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified …
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified …