This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

The majority of insect olfactory receptors belong to two distinct protein families, the
ionotropic receptors (IRs), which are related to the ionotropic glutamate receptor family, and …

Brains comprise complex networks of neurons and connections, similar to the nodes and
edges of artificial networks. Network analysis applied to the wiring diagrams of brains can …

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …

Similarity search—for example, identifying similar images in a database or similar
documents on the web—is a fundamental computing problem faced by large-scale …

Internal states shape stimulus responses and decision-making, but we lack methods to
identify them. To address this gap, we developed an unsupervised method to identify …

The hemibrain connectome provides large-scale connectivity and morphology information
for the majority of the central brain of Drosophila melanogaster. Using this data set, we …

Remarkable advances in our understanding of olfactory perception have been made in
recent years, including the discovery of new mechanisms of olfactory signaling and new …

Internal physiological states influence behavioral decisions. We have investigated the
underlying cellular and molecular mechanisms at the first olfactory synapse for starvation …

In many regions of the visual system, the activity of a neuron is normalized by the activity of
other neurons in the same region. Here we show that a similar normalization occurs during …