A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Promising treatment options have emerged from research in recent years using
neurostimulation to enable or enhance intense training. However, characterizing long-term …

Descending command neurons instruct spinal networks to execute basic locomotor
functions, such as gait and speed. The command functions for gait and speed are symmetric …

Locomotion empowers animals to move. Locomotor-initiating signals from the brain are
funneled through descending neurons in the brainstem that act directly on spinal locomotor …

Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to
rehabilitation and daily activities. Pharmacological management of spasms mostly targets …

After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating
condition involving involuntary movements, co-contraction of antagonistic muscles, and …

Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for
spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem …

The ability to manipulate specific neuronal populations of the spinal cord following spinal
cord injury (SCI) could prove highly beneficial for rehabilitation in patients through …

Spinal motoneuron firing depends greatly on persistent inward currents (PICs), which in turn
are facilitated by the neuromodulators serotonin and noradrenaline. The aim of this study …

Spinal cord injury leads to a devastating loss of motor function and yet is accompanied by a
paradoxical emergence of muscle spasms, which often involve complex muscle activation …