Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

The ribotoxic stress response (RSR) is a signaling pathway in which the p38-and c-Jun N-
terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) …

Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in
ribosomal collisions. Collided ribosomes are specifically recognized to initiate stress …

Ribosomes frequently stall during mRNA translation, resulting in the context-dependent
activation of quality control pathways to maintain proteostasis. However, surveillance …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

Impairment of protein translation can cause stalling and collision of ribosomes and is a
signal for the activation of ribosomal surveillance and rescue pathways. Despite clear …

Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and
promotes host RNA decay. However, it is unclear how these two activities are connected …

Cells tightly regulate mRNA processing, localization, and stability to ensure accurate gene
expression in diverse cellular states and conditions. Most of these regulatory steps have …

Ribosome profiling, which is based on deep sequencing of ribosome footprints, has served
as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However …