Asthma is a serious health and socioeconomic issue all over the world, affecting more than
300 million individuals. The disease is considered as an inflammatory disease in the airway …

Asthma is an inflammatory disorder of the airways involving coordinate up-regulation of TH2-
type cytokines encoded in a cluster on chromosome 5q31-33 on T cells and inflammatory …

House dust mite (HDM) is one of the most common allergens worldwide. In this study, we
have addressed the involvement of IL-1 in the interaction between HDM and the innate …

Întegrins, matrix metalloproteases (MMPs), and the cytokine TGF-β have each been
implicated in homeostatic cell behaviors such as cell growth and matrix remodeling. TGF-β …

BIBF 1000 is a small molecule inhibitor targeting the receptor kinases of platelet-derived
growth factor (PDGF), basic fibroblast growth factor and vascular endothelial growth factor …

In previous studies, we demonstrated that allergenic house dust mite proteases are potent
inducers of proinflammatory cytokines from the respiratory epithelium, although the precise …

Chronic obstructive pulmonary disease (COPD) is a common lung disease with cigarette
smoking as the major etiological factor, but only 15% of smokers develop COPD. Destruction …

The importance of mast cells in the development of the allergen-induced airway
hyperreactivity and inflammation associated with asthma remains controversial. We found …

Inhaled diesel exhaust particles (DEP) exert proinflammatory effects in the respiratory tract.
This effect is related to the particle content of redox cycling chemicals and is involved in the …

Background: Allergic respiratory diseases are characterized by large numbers of
eosinophils and their reactive products in airways and blood; these are believed to be …