[HTML][HTML] Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment—Progresses in Their Use in Combined Cancer …
A Povo-Retana, R Landauro-Vera, C Alvarez-Lucena… - Molecules, 2024 - mdpi.com
Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from
Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural …
Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural …
[HTML][HTML] Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
M Podolak, S Holota, Y Deyak, K Dziduch… - Bioorganic …, 2023 - Elsevier
Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
[HTML][HTML] Synthetic Approaches to Piperazine-Containing Drugs Approved by FDA in the Period of 2011–2023
MN Romanelli, L Braconi, A Gabellini, D Manetti… - Molecules, 2023 - mdpi.com
The piperazine moiety is often found in drugs or in bioactive molecules. This widespread
presence is due to different possible roles depending on the position in the molecule and on …
presence is due to different possible roles depending on the position in the molecule and on …
[HTML][HTML] Eribulin in breast cancer: Current insights and therapeutic perspectives
Eribulin is a non-taxane synthetic analogue approved in many countries as third-line
treatment for the treatment of patients with metastatic breast cancer. In addition to its mitotic …
treatment for the treatment of patients with metastatic breast cancer. In addition to its mitotic …
[HTML][HTML] Effect of the Marine Polyketide Plocabulin on Tumor Progression
E Turrini, F Maffei, C Fimognari - Marine Drugs, 2022 - mdpi.com
Marine sponges represent one of the richest sources of natural marine compounds with
anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the …
anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the …