The process of cell division plays a vital role in cancer progression. Cell proliferation and
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …

Degrons are the elements that are used by E3 ubiquitin ligases to target proteins for
degradation. Most degrons are short linear motifs embedded within the sequences of …

Background Recently, the dysregulation of circular RNA (circRNA) have been shown to
have important regulatory roles in cancer development and progression, including …

Anti-transcription intermediary factor 1 (TIF1)-γ autoantibodies are robustly linked with
cancer-associated DM in adults. This review aims to give an overview of the physiological …

Autoimmune myopathies (myositides) are strongly associated with malignancy. The link
between myositis and cancer, originally noticed by Bohan and Peter in their classification in …

Genomic instability is a hallmark of cancer cells which results in excessive DNA damage. To
counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to …

Objectives To analyse the influence of genetic alterations and differential expression of
transcription intermediary factor 1 (TIF1) genes in the pathophysiology of cancer-associated …

TRIM proteins constitute a large, diverse and ancient protein family which play a key role in
processes including cellular differentiation, autophagy, apoptosis, DNA repair, and tumour …

Transcriptional intermediary factor 1 γ (TIF1γ), also known as TRIM33, RFG7, PTC7, or
Ectodermin, is an E3 ubiquitin-ligase family member with a ring-box-coiled-coil region. It can …

Productive HIV-1 replication requires viral integrase (IN), which catalyzes integration of the
viral genome into the host cell DNA. IN, however, is short lived and is rapidly degraded by …