Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …

Objectives Increasing evidence suggests that inflammation is involved in Alzheimer's
disease (AD) pathology. This study quantitatively summarised the data on peripheral …

Poor diet and obesity are associated with cognitive impairment throughout adulthood, and
increased dementia risk in aging. Here we review the current literature interrogating the …

Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued
development and standardization of methodologies for biomarkers and has provided an …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Receptors of leptin, the prototypical adipokine, are expressed throughout the cortex and
several other areas of the brain. Although typically studied for its role in energy intake and …

Alzheimer's disease (AD) is an irreversible, progressive disease that slowly destroys
cognitive function, such as thinking, remembering, and reasoning, to a level that one cannot …

Despite significant advances in current understanding of mechanisms of pathogenesis in
Alzheimer's disease (AD), attempts at drug development based on those discoveries have …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, the development of
which is regulated by several environmental and genetic risk factors. Two factors theorized …

Background Metabolic dysfunction and dysregulation of leptin signaling have been linked to
Alzheimer's disease (AD)'s pathophysiology. The objectives of this study were to examine …