Key chemokines direct migration of immune cells in solid tumors
Immune cell infiltration into solid tumors, their movement within the tumor microenvironment
(TME), and interaction with other immune cells are controlled by their directed migration …
(TME), and interaction with other immune cells are controlled by their directed migration …
The CCL5/CCR5 axis in cancer progression
D Aldinucci, C Borghese, N Casagrande - Cancers, 2020 - mdpi.com
Tumor cells can “hijack” chemokine networks to support tumor progression. In this context,
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …
Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
P Bule, SI Aguiar, F Aires-Da-Silva… - International journal of …, 2021 - mdpi.com
Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …
Recent advances targeting CCR5 for cancer and its role in immuno-oncology
X Jiao, O Nawab, T Patel, AV Kossenkov, N Halama… - Cancer research, 2019 - AACR
Experiments of nature have revealed the peculiar importance of the G-protein–coupled
receptor, CC chemokine receptor type 5 (CCR5), in human disease since ancient times. The …
receptor, CC chemokine receptor type 5 (CCR5), in human disease since ancient times. The …
Tumor immunogenic cell death as a mediator of intratumor CD8 T-cell recruitment
The success of anticancer treatments relies on a long-term response which can be mediated
by the immune system. Thus, the concept of immunogenic cell death (ICD) describes the …
by the immune system. Thus, the concept of immunogenic cell death (ICD) describes the …
Inhibition of the CCL5/CCR5 axis against the progression of gastric cancer
D Aldinucci, N Casagrande - International journal of molecular sciences, 2018 - mdpi.com
Despite the progress made in molecular and clinical research, patients with advanced-stage
gastric cancer (GC) have a bad prognosis and very low survival rates. Furthermore, it is …
gastric cancer (GC) have a bad prognosis and very low survival rates. Furthermore, it is …
The role and therapeutic targeting of CCR5 in breast cancer
R Hamid, M Alaziz, AS Mahal, AW Ashton, N Halama… - Cells, 2023 - mdpi.com
The G-protein-coupled receptor CC chemokine receptor 5 (CCR5) functions as a co-
receptor for the entry of HIV into immune cells. CCR5 binds promiscuously to a diverse array …
receptor for the entry of HIV into immune cells. CCR5 binds promiscuously to a diverse array …
Cytokine regulation of metastasis and tumorigenicity
The human body combats infection and promotes wound healing through the remarkable
process of inflammation. Inflammation is characterized by the recruitment of stromal cell …
process of inflammation. Inflammation is characterized by the recruitment of stromal cell …
CCL5 secreted by tumor associated macrophages may be a new target in treatment of gastric cancer
H Ding, L Zhao, S Dai, L Li, F Wang, B Shan - Biomedicine & …, 2016 - Elsevier
Aim To investigate the role of CCL5 secreted by tumor associated macrophages (TAMs) in
gastric cancer, and to explore how CCL5/CCR5 axis modulates phenotypes of gastric …
gastric cancer, and to explore how CCL5/CCR5 axis modulates phenotypes of gastric …
Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy
Background Triple-negative breast cancer (BCa)(TNBC) is a deadly form of human BCa with
limited treatment options and poor prognosis. In our prior analysis of over 2200 breast …
limited treatment options and poor prognosis. In our prior analysis of over 2200 breast …