The impact of the gut microbiome on extra-intestinal autoimmune diseases

E Miyauchi, C Shimokawa, A Steimle… - Nature Reviews …, 2023 - nature.com
The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

W Yang, Y Cong - Cellular & molecular immunology, 2021 - nature.com
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Lupus nephritis

HJ Anders, R Saxena, M Zhao, I Parodis… - Nature reviews Disease …, 2020 - nature.com
Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …

Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity

Y Kinashi, K Hase - Frontiers in immunology, 2021 - frontiersin.org
The intestinal surface is constitutively exposed to diverse antigens, such as food antigens,
food-borne pathogens, and commensal microbes. Intestinal epithelial cells have developed …

Systemic lupus erythematosus: new diagnostic and therapeutic approaches

S Lazar, JM Kahlenberg - Annual review of medicine, 2023 - annualreviews.org
Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that can result in
substantial morbidity and mortality. Diagnosis and treatment of SLE are clinical challenges …

Causal effects of gut microbiome on systemic lupus erythematosus: a two-sample Mendelian randomization study

K Xiang, P Wang, Z Xu, YQ Hu, YS He, Y Chen… - Frontiers in …, 2021 - frontiersin.org
The observational association between gut microbiome and systemic lupus erythematosus
(SLE) has been well documented. However, whether the association is causal remains …

Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: Recent challenges and …

T Aziz, N Hussain, Z Hameed, L Lin - Gut Microbes, 2024 - Taylor & Francis
ABSTRACT A healthy balanced diet is crucial in protecting the immune system against
infections and diseases. Poor diets, such as the Western diet, contribute to the development …

Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer

V Lazar, LM Ditu, GG Pircalabioru, I Gheorghe… - Frontiers in …, 2018 - frontiersin.org
The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea,
and protozoans, bringing to the host organism a dowry of cells and genes more numerous …

New insights into the immunopathogenesis of systemic lupus erythematosus

GC Tsokos, MS Lo, PC Reis, KE Sullivan - Nature Reviews …, 2016 - nature.com
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Signals from the gut microbiota to distant organs in physiology and disease

BO Schroeder, F Bäckhed - Nature medicine, 2016 - nature.com
The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is
fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived …