Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Wound management in diabetic patient is of an extreme clinical and social concern. The
delayed and impaired healing makes it more critical for research focus. The research on …

The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

Background Exosomes are nanovesicles secreted by tumour cells which have roles in
paracrine signalling during tumour progression, including tumour-stromal interactions …

microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were
found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating …

Hypoxia is a physiological cue that impacts diverse physiological processes, including
energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the …

Significance: Poor wound healing remains a significant health issue for a large number of
patients in the United States. The physiologic response to local wound hypoxia plays a …

The bubbling community of microorganisms, consisting of diverse colonies encased in a self-
produced protective matrix and playing an essential role in the persistence of infection and …