Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is
used for recycling cytoplasm to generate macromolecular building blocks and energy under …

An enigmatic step in de novo formation of the autophagosome membrane compartment is
the expansion of the precursor membrane phagophore, which requires the acquisition of …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

Mammalian cell homeostasis during starvation depends on initiation of autophagy by
endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns (3) P) synthesis …

The biogenesis of double-membrane vesicles called autophagosomes, which sequester
and transport intracellular material for degradation in lysosomes or vacuoles, is a central …

Autophagy is a major intracellular degradative process that delivers cytoplasmic materials to
the lysosome for degradation. Since the discovery of autophagy-related (Atg) genes in the …

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …