Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic joint
inflammation and bone erosion. The bones in the human body are constantly undergoing …

In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of
ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC …

Bone growth and the maintenance of bone structure are controlled by multiple endocrine
and paracrine factors, including cytokines expressed locally within the bone …

Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) have
been shown to function downstream of several peptide hormones and cytokines that are …

Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory
diseases including rheumatoid arthritis (RA), irritable bowel disease and lupus. Maladaptive …

Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine
signaling, tissue homeostasis, and cancer development. Using a breast cancer model that …

The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signaling
pathway serves as an important downstream mediator for a variety of cytokines, hormones …

Inflammatory diseases are frequently treated with Janus kinase (JAK) inhibitors to diminish
cytokine signaling. These treatments can lead to inadvertent immune suppression and may …

Summary Interleukin-6 (IL-6)-class inflammatory cytokines signal through the Janus tyrosine
kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and promote …

Peak lactation occurs when milk production is at its highest. The factors limiting peak
lactation performance have been subject of intense debate. Milk production at peak lactation …