Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines

S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …

Novel investigational anti-SARS-CoV-2 agent ensitrelvir “S-217622”: a very promising potential universal broad-spectrum antiviral at the therapeutic frontline of …

WA Eltayb, M Abdalla, AM Rabie - ACS omega, 2023 - ACS Publications
Lately, nitrogenous heterocyclic antivirals, such as nucleoside-like compounds, oxadiazoles,
thiadiazoles, triazoles, quinolines, and isoquinolines, topped the therapeutic scene as …

Promising experimental anti-SARS-CoV-2 agent “SLL-0197800”: the prospective universal inhibitory properties against the coming versions of the coronavirus

AM Rabie, MA Abdel-Dayem, M Abdalla - ACS omega, 2023 - ACS Publications
Isoquinoline derivatives having some nucleosidic structural features are considered as
candidate choices for effective remediation of the different severe acute respiratory …

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture

X Wang, CQ Sacramento, S Jockusch… - Communications …, 2022 - nature.com
SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …

Forodesine and Riboprine Exhibit Strong Anti-SARS-CoV-2 Repurposing Potential: In Silico and In Vitro Studies

AM Rabie, M Abdalla - ACS bio & med Chem Au, 2022 - ACS Publications
Lately, nucleos (t) ide antivirals topped the scene as top options for the treatment of
coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome …

Coronavirus genomic nsp14‐ExoN, structure, role, mechanism, and potential application as a drug target

M Tahir - Journal of Medical Virology, 2021 - Wiley Online Library
The recent coronavirus disease 2019 (COVID‐19), causing a global pandemic with
devastating effects on healthcare and social‐economic systems, has no special antiviral …

Antiviral phytocompounds “ellagic acid” and “(+)-sesamin” of Bridelia retusa identified as potential inhibitors of SARS-CoV-2 3CL pro using extensive molecular …

AK Umar, JH Zothantluanga, K Aswin, S Maulana… - Structural …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected billions and
has killed millions to date. Studies are being carried out to find therapeutic molecules that …

A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites

MJ Islam, NN Islam, MS Alom, M Kabir, MA Halim - Immunobiology, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …

Glycyrrhizin as a promising kryptonite against SARS-CoV-2: Clinical, experimental, and theoretical evidences

S Banerjee, SK Baidya, N Adhikari, B Ghosh… - Journal of Molecular …, 2023 - Elsevier
COVID-19 is the most devastating disease in recent times affecting most people globally.
The higher rate of transmissibility and mutations of SARS-CoV-2 along with the lack of …