Structural biology of SARS-CoV-2: open the door for novel therapies
W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines
S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
Novel investigational anti-SARS-CoV-2 agent ensitrelvir “S-217622”: a very promising potential universal broad-spectrum antiviral at the therapeutic frontline of …
Lately, nitrogenous heterocyclic antivirals, such as nucleoside-like compounds, oxadiazoles,
thiadiazoles, triazoles, quinolines, and isoquinolines, topped the therapeutic scene as …
thiadiazoles, triazoles, quinolines, and isoquinolines, topped the therapeutic scene as …
Promising experimental anti-SARS-CoV-2 agent “SLL-0197800”: the prospective universal inhibitory properties against the coming versions of the coronavirus
Isoquinoline derivatives having some nucleosidic structural features are considered as
candidate choices for effective remediation of the different severe acute respiratory …
candidate choices for effective remediation of the different severe acute respiratory …
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture
X Wang, CQ Sacramento, S Jockusch… - Communications …, 2022 - nature.com
SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
Forodesine and Riboprine Exhibit Strong Anti-SARS-CoV-2 Repurposing Potential: In Silico and In Vitro Studies
Lately, nucleos (t) ide antivirals topped the scene as top options for the treatment of
coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome …
coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome …
Coronavirus genomic nsp14‐ExoN, structure, role, mechanism, and potential application as a drug target
M Tahir - Journal of Medical Virology, 2021 - Wiley Online Library
The recent coronavirus disease 2019 (COVID‐19), causing a global pandemic with
devastating effects on healthcare and social‐economic systems, has no special antiviral …
devastating effects on healthcare and social‐economic systems, has no special antiviral …
Antiviral phytocompounds “ellagic acid” and “(+)-sesamin” of Bridelia retusa identified as potential inhibitors of SARS-CoV-2 3CL pro using extensive molecular …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected billions and
has killed millions to date. Studies are being carried out to find therapeutic molecules that …
has killed millions to date. Studies are being carried out to find therapeutic molecules that …
A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …
Glycyrrhizin as a promising kryptonite against SARS-CoV-2: Clinical, experimental, and theoretical evidences
COVID-19 is the most devastating disease in recent times affecting most people globally.
The higher rate of transmissibility and mutations of SARS-CoV-2 along with the lack of …
The higher rate of transmissibility and mutations of SARS-CoV-2 along with the lack of …