Genetics in ophthalmology: molecular blueprints of retinoblastoma

L Marković, A Bukovac, AM Varošanec, N Šlaus… - Human Genomics, 2023 - Springer
This review presents current knowledge on the molecular biology of retinoblastoma (RB).
Retinoblastoma is an intraocular tumor with hereditary and sporadic forms. 8,000 new cases …

[HTML][HTML] Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities

AS Venkataramany, KM Schieffer, K Lee, CE Cottrell… - Annals of …, 2022 - Elsevier
Background Compared with adult cancers, pediatric cancers are uniquely characterized by
a genomically stable landscape and lower tumor mutational burden. Alternative splicing …

[HTML][HTML] Retinoblastoma: A review of the molecular basis of tumor development and its clinical correlation in shaping future targeted treatment strategies

S Rathore, A Verma, R Ratna, N Marwa… - Indian Journal of …, 2023 - journals.lww.com
Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular
tumor worldwide. Despite tremendous breakthroughs in our understanding of the …

pRB-depleted pluripotent stem cell retinal organoids recapitulate cell state transitions of retinoblastoma development and suggest an important role for pRB in retinal …

A Rozanska, R Cerna-Chavez, R Queen… - Stem Cells …, 2022 - academic.oup.com
Retinoblastoma (Rb) is a childhood cancer of the developing retina, accounting for up to
17% of all tumors in infancy. To gain insights into the transcriptional events of cell state …

Long noncoding RNA LINC00202 promotes tumor progression by sponging miR-3619-5p in retinoblastoma

G Yan, Y Su, Z Ma, L Yu, N Chen - Cell structure and function, 2019 - jstage.jst.go.jp
Retinoblastoma (RB) is the most common intraocular malignancy in childhood, and the
prognosis in the advanced RB is poor. It is urgent to find novel therapeutic targets. Long …

Integrated analysis of cancer tissue and vitreous humor from retinoblastoma eyes reveals unique tumor-specific metabolic and cellular pathways in advanced and non …

VS Babu, A Mallipatna, D Sa, G Dudeja, R Kannan… - Cells, 2022 - mdpi.com
Retinoblastoma (Rb) is a pediatric intraocular malignancy that is proposed to originate from
maturing cone cell precursors in the developing retina. The molecular mechanisms …

Identification of dysregulation of sphingolipids in retinoblastoma using liquid chromatography-mass spectrometry

OS Khade, S Sasidharan, A Jain, BS Maradani… - Experimental Eye …, 2024 - Elsevier
Retinoblastoma (RB) is a rare ocular cancer seen in children that counts for approximately
3% of all childhood cancers. It is found that mutation in RB1, a tumour Suppressor Gene on …

[HTML][HTML] RNA sequencing of early-stage gastric adenocarcinoma reveals multiple activated pathways and novel long non-coding RNAs in patient tissue samples

S Fattahi, N Nikbakhsh, H Taheri… - … of biochemistry & …, 2021 - ncbi.nlm.nih.gov
Background: Gastric cancer is among the most common cancers worldwide that currently
lacks effective diagnostic biomarkers and therapeutic targets. Next-generation RNA …

Retinoblastoma and mosaic 13q deletion: a case report

P Gargallo, S Oltra, J Balaguer, H Barranco… - International Journal of …, 2021 - Springer
Background Patients with 13q-syndrome are at risk of retinoblastoma when the RB1 gene,
located in the chromosomal band 13q14. 2, is deleted. This syndrome is frequently …

Post-transcriptional Regulation in Tumorigenesis

S Rajasekaran - 2022 - rave.ohiolink.edu
Cancer is a leading cause of death in the United States and accounts for about $209.8
billion of the financial burden on the United States healthcare system. One of the most …