Human hepatitis B virus (HBV) is a small enveloped DNA virus with a complex life cycle. It is
the causative agent of acute and chronic hepatitis. HBV can resist immune system …

The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77
members known in the human, most of which consist of a RING-finger domain, one or two B …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative
pathogen of current COVID-19 pandemic, and insufficient production of type I interferon (IFN …

The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of ongoing global pandemic of COVID-19, may trigger …

Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in
patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis …

Conclusions: Our study unravels a previously unknown mechanism of action for CAM-As
such as RG7907 in which HBc aggregation induces cell death, resulting in hepatocyte …

Chronic hepatitis B virus (HBV) infection is an international health problem with extremely
high mortality and morbidity rates. Although current clinical chronic hepatitis B (CHB) …

Members of the tripartite motif (TRIM) protein family strongly induced by interferons (IFNs)
are parts of the innate immune system with antiviral activity. However, it is still unclear which …

Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has led to an unprecedented public health crisis worldwide. Though the host …

As a cytosol ubiquitin ligase and antibody receptor, Tripartite motif-containing 21 (TRIM21)
has been reported to mediate the restriction of hepatitis B virus (HBV) through an HBx …