▪ Abstract The polarized architecture of epithelial cells and tissues is a fundamental
determinant of animal anatomy and physiology. Recent progress made in the genetic and …

The cross-regulation of Wnt/β-catenin/Tcf ligands, kinases, and transcription factors with
members of the nuclear receptor (NR) family has emerged as a clinically and …

As a component of adherens junctions and the Wnt signaling pathway, β-catenin binds
cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have …

The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer
binding factor) interact with β-catenin and are hypothesized to mediate Wingless/Wnt …

Abstract β-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth
factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the …

Overexpression of myc protooncogenes has been implicated in the genesis of many human
tumors. Myc proteins seem to regulate diverse biological processes, but their role in …

Wnt/Wingless signaling controls many fundamental processes during animal development.
Wnt transduction is mediated by the association of β-catenin with nuclear TCF DNA binding …

Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of
various malignancies, including colorectal carcinomas, and it is a key therapeutic target in …

The Wnt signaling pathway plays critical roles in embryonic development and
tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear β …

Wnt/β-catenin signaling is a highly conserved pathway essential for embryogenesis and
tissue homeostasis. However, deregulation of this pathway can initiate and promote human …