Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Cell refractive index for cell biology and disease diagnosis: past, present and future

PY Liu, LK Chin, W Ser, HF Chen, CM Hsieh, CH Lee… - Lab on a Chip, 2016 - pubs.rsc.org
Cell refractive index is a key biophysical parameter, which has been extensively studied. It is
correlated with other cell biophysical properties including mechanical, electrical and optical …

Quantitative phase imaging in biomedicine

YK Park, C Depeursinge, G Popescu - Nature photonics, 2018 - nature.com
Quantitative phase imaging (QPI) has emerged as a valuable method for investigating cells
and tissues. QPI operates on unlabelled specimens and, as such, is complementary to …

Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning

YJ Jo, H Cho, WS Park, G Kim, DH Ryu, YS Kim… - Nature Cell …, 2021 - nature.com
Simultaneous imaging of various facets of intact biological systems across multiple
spatiotemporal scales is a long-standing goal in biology and medicine, for which progress is …

Computational illumination for high-speed in vitro Fourier ptychographic microscopy

L Tian, Z Liu, LH Yeh, M Chen, J Zhong, L Waller - Optica, 2015 - opg.optica.org
We demonstrate a new computational illumination technique that achieves a large space–
bandwidth–time product, for quantitative phase imaging of unstained live samples in vitro …

[HTML][HTML] Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications

KR Lee, K Kim, J Jung, JH Heo, S Cho, S Lee… - Sensors, 2013 - mdpi.com
A cellular-level study of the pathophysiology is crucial for understanding the mechanisms
behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques …

Quantitative phase imaging and artificial intelligence: a review

YJ Jo, H Cho, SY Lee, G Choi, G Kim… - IEEE Journal of …, 2018 - ieeexplore.ieee.org
Recent advances in quantitative phase imaging (QPI) and artificial intelligence (AI) have
opened up the possibility of an exciting frontier. The fast and label-free nature of QPI …

[HTML][HTML] The regulation of cell size

AC Lloyd - Cell, 2013 - cell.com
An adult animal consists of cells of vastly different size and activity, but the regulation of cell
size remains poorly understood. Recent studies uncovering some of the signaling pathways …

[HTML][HTML] Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments

ME Kandel, YR He, YJ Lee, THY Chen… - Nature …, 2020 - nature.com
Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in
cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit …

White-light diffraction tomography of unlabelled live cells

T Kim, R Zhou, M Mir, SD Babacan, PS Carney… - Nature …, 2014 - nature.com
We present a technique called white-light diffraction tomography (WDT) for imaging
microscopic transparent objects such as live unlabelled cells. The approach extends …