The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

Platinating agents, including cisplatin, carboplatin, and oxaliplatin, have been used clinically
for nearly 30years as part of the treatment of many types of cancers, including head and …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of
cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water …

Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years
ago, a deep understanding of the chemical and biochemical transformations giving rise to its …

Abstract Cisplatin [cis-DDP, cis-diamminedichloroplatinum (II)] is a potent anticancer drug
that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary …

Cisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer
cells cope with the drug by removal of the damages with nucleotide excision repair. We have …

Oxaliplatin, a diaminocyclohexane-containing platinum, has a spectrum of activity and
mechanisms of action and resistance that appear to be different from those of other platinum …

Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have
similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The …