Human kidney stones: a natural record of universal biomineralization

M Sivaguru, JJ Saw, EM Wilson, JC Lieske… - Nature Reviews …, 2021 - nature.com
GeoBioMed—a new transdisciplinary approach that integrates the fields of geology, biology
and medicine—reveals that kidney stones composed of calcium-rich minerals precipitate …

Mechanisms of the intestinal and urinary microbiome in kidney stone disease

AW Miller, KL Penniston, K Fitzpatrick… - Nature Reviews …, 2022 - nature.com
Kidney stone disease affects~ 10% of the global population and the incidence continues to
rise owing to the associated global increase in the incidence of medical conditions …

Urinary stone composition in Germany: results from 45,783 stone analyses

R Siener, H Herwig, J Rüdy, RM Schaefer… - World Journal of …, 2022 - Springer
Purpose Stone composition can provide valuable information for the diagnosis, treatment
and recurrence prevention of urolithiasis. The aim of this study was to evaluate the …

[HTML][HTML] Liquid-liquid phase separation in nucleation process of biomineralization

D Qin, Z He, P Li, S Zhang - Frontiers in Chemistry, 2022 - frontiersin.org
Biomineralization is a typical interdisciplinary subject attracting biologists, chemists, and
geologists to figure out its potential mechanism. A mounting number of studies have …

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

M Maruyama, KP Sawada, Y Tanaka, A Okada… - Plos one, 2023 - journals.plos.org
We sought to identify and quantitatively analyze calcium oxalate (CaOx) kidney stones on
the order of micrometers, with a focus on the quantitative identification of calcium oxalate …

Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease

M Maruyama, Y Tanaka, K Momma… - Crystal Growth & …, 2023 - ACS Publications
In this study, we investigated calcium oxalate (CaOx) kidney stones and showed direct
evidence of the solution-mediated phase transition of calcium oxalate dihydrate (COD; the …

[HTML][HTML] Multimodal imaging reveals a unique autofluorescence signature of Randall's plaque

S Winfree, C Weiler, SB Bledsoe, T Gardner… - Urolithiasis, 2021 - Springer
Kidney stones frequently develop as an overgrowth on Randall's plaque (RP) which is
formed in the papillary interstitium. The organic composition of RP is distinct from stone …

Comparative functional analysis of the urinary tract microbiome for individuals with or without calcium oxalate calculi

N Kachroo, M Monga, AW Miller - Urolithiasis, 2022 - Springer
Individuals with urinary stone disease (USD) exhibit dysbiosis in the urinary tract and the
loss of Lactobacillus that promote urinary tract health. However, the microbial metabolic …

Kidney stone growth through the lens of Raman mapping

JW Robinson, WW Roberts, AJ Matzger - Scientific Reports, 2024 - nature.com
Bulk composition of kidney stones, often analyzed with infrared spectroscopy, plays an
essential role in determining the course of treatment for kidney stone disease. Though bulk …

Application of metabolomics in urolithiasis: the discovery and usage of succinate

X Zhang, X Lei, Y Jiang, L Zhao, C Zou, Y Bai… - … and Targeted Therapy, 2023 - nature.com
Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic
stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) …