Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …

Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …

Upon penetration of the influenza virus nucleocapsid into the host cell cytoplasm, the viral
RNA and associated proteins are transported to the nucleus, where viral transcription and …

Laminopathies are a group of disorders caused by mutations in the LMNA gene that
encodes the nuclear lamina proteins, lamin A and lamin C; their pathophysiological basis is …

Using a solution binding assay, we show that purified 125I-labeled lamin B binds in a
saturable and specific fashion to lamin-depleted avian erythrocyte nuclear membranes with …

Mutations in emerin cause the X-linked recessive form of Emery-Dreifuss muscular
dystrophy (EDMD). Emerin localizes at the inner membrane of the nuclear envelope (NE) …

The nucleus of eukaryotic cells contains a distinct set of proteins necessary for the
management of genes. Following synthesis in the cytoplasm, proteins enter the nucleus …

The nuclear envelope is composed of membranes, nuclear pores, and a nuclear lamina.
Using a cell-free nuclear assembly extract derived from Xenopus eggs, we have …

The nuclear lamina is a fundamental component involved in the assembly of the nuclear
envelope and higher order chromosomal structures in eukaryotes. In mammals, it is …

Desmin, the muscle-specific memberof the intermediate filament (IF) family, is one of the
earliest knownmyogenicmarkers in both skeletal muscleand heart. Its expression precedes …