Transthyretin (ATTR) amyloidosis is a life-threatening, gain-of-toxic-function disease
characterised by extracellular deposition of amyloid fibrils composed of transthyretin (TTR) …

Oligomeric intermediates are non-fibrillar polypeptide assemblies that occur during amyloid
fibril formation and that are thought to underlie the aetiology of amyloid diseases, such as …

Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (ie,
undergo amyloidogenesis) in vivo. The process of TTR amyloidogenesis causes nervous …

Parkinson's disease (PD) is a neurological disorder marked by the presence of cytoplasmic
inclusions, Lewy bodies (LBs) and Lewy neurites (LNs) as well as the degeneration of …

Transthyretin (TTR) is a homotetrameric protein mainly synthesised by the liver and the
choroid plexus whose function is to carry the thyroid hormone thyroxine and the retinol …

Amyloidosis is a protein folding disorder in which normally soluble proteins are deposited
extracellularly as insoluble fibrils, impairing tissue structure and function. Charged …

Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

Aggregation of the amyloid-β (Aβ) peptide is strongly correlated with Alzheimer's disease
(AD). Recent research has improved our understanding of the kinetics of amyloid fibril …

Different proteins have different amino acid sequences as well as conformations, and
therefore different propensities to aggregate. Electrostatic interactions have an important …

Several human degenerative diseases involve amyloidogenic peptides/proteins with high
conformational plasticity and propensity to self-aggregate into polymeric fibrillar assemblies …