Computational tools for discovering and engineering natural product biosynthetic pathways

H Ren, C Shi, H Zhao - Iscience, 2020 - cell.com
Natural products (NPs), also known as secondary metabolites, are produced in bacteria,
fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer …

Synthetic cross-phyla gene replacement and evolutionary assimilation of major enzymes

TE Sandberg, R Szubin, PV Phaneuf… - Nature ecology & …, 2020 - nature.com
The ability of DNA to produce a functional protein even after transfer to a foreign host is of
fundamental importance in both evolutionary biology and biotechnology, enabling horizontal …

Computational pipeline for targeted integration and variable payload expression for bacteriophage engineering.

J Fernbach, E Hegedis, MJ Loessner, S Kilcher - bioRxiv, 2024 - biorxiv.org
Bacteriophages offer a promising alternative to conventional antimicrobial treatments,
particularly in cases where such treatments have proven ineffective. While naturally …

Progress in research on Lactococcus lactis expression systems and their promoter regulatory elements.

H Wang, X Lao, L Huang, Y Fang, Z Xiong, L Ai… - 2022 - cabidigitallibrary.org
Lactococcus lactis, an important model strain for industrial applications, is an ideal host for
heterologous protein expression and secretion because of its non-pathogenic nature, high …

Núcleo de Pesquisa em Bioinformática da Universidade de Caxias do Sul: 12 anos de história

FP de Abreu, PL Casa, NS de Oliveira… - … Journal of Applied …, 2021 - sou.ucs.br
Bioinformatics comprises a multidisciplinary field that brings together researchers from areas
of life sciences and computer science. Its repercussion at the Universidade de Caxias do Sul …

Exploring the Adaptive Capabilities of Escherichia coli: Perturbations from a Typical Life Cycle and Resulting Evolutionary Compensations

T Sandberg - 2018 - escholarship.org
Evolution underlies the entirety of Earth's biodiversity, as all species diverged from the last
universal common ancestor billions of years ago. Although able to effect incredible changes …