A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …

Neuroprotection and brain repair in patients after acute brain damage are still major
unfulfilled medical needs. Pharmacological treatments are either ineffective or confounded …

Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

The synthesis, release, reuptake, and metabolism of the excitatory and inhibitory
neurotransmitters glutamate and GABA, respectively, are tightly controlled. Given the role …

Cerebral ischemia/reperfusion (I/R) injury triggers multiple and distinct but overlapping cell
signaling pathways, which may lead to cell survival or cell damage. There is overwhelming …

Cerebral damage as a consequence of glutamate-mediated excitotoxicity represents a
major consequence of stroke. However, the development of effective clinical treatments for …