Diabetic nephropathy (DN) remains the leading cause of vascular morbidity and mortality in
diabetes patients. Despite the progress in understanding the diabetic disease process and …

Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which
cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell …

Type 2 diabetes mellitus (T2D) affects millions of people around the world, and its
complications have serious health consequences. In addition to external factors, the causes …

The biological basis underlying cognitive dysfunction in women with early-stage breast
cancer (BC) remains unclear, but could reflect gene expression changes that arise from the …

Promoters are DNA non-coding regions around the transcription start site and are
responsible for regulating the gene transcription process. Due to their key role in gene …

Results Treatment of RGE cells with HG induced significant cytotoxicity and increased
expression levels of RIP1, RIP3 and p-p38MAPK, which were abrogated by Apn in a …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases with important roles
in kidney homeostasis and pathology. While capable of collectively degrading each …

Background Diabetic nephropathy is a highly destructive microvascular complication of
diabetes. Genetic predisposition is involved in the pathogenesis of diabetic nephropathy …

Matrix metalloproteinases (MMPs) are a family of zinc-activated peptidases that can be
classified into six major classes, including gelatinases, collagenases, stromelysins …

Aims Genetic variations mediating MMP-2 expression may result in individual differences in
susceptibility to particular diseases. Our aim was to investigate the possible association of …