One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …

Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …

In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

Microtubules play an important role in the process of cell mitosis and can form a spindle in
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …

In spite of substantial progress made toward understanding cancer pathogenesis, this
disease remains one of the leading causes of mortality. Thus, there is an urgent need to …

Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Histaminium tetrachlorozincate nanoparticles are prepared, characterized and applied as an
effective and recoverable photocatalyst in the one-pot, green and multi-component synthesis …

Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer
targets for decades. Six known binding sites on tubulin dimers have been identified thus far …

In recent years, suppressing tubulin polymerization has been developed as a therapeutic
approach for cancer treatment. Thus, new derivatives based on thiazol-5 (4H)-ones have …