G protein-coupled receptors as promising cancer targets
Y Liu, S An, R Ward, Y Yang, XX Guo, W Li, TR Xu - Cancer letters, 2016 - Elsevier
G protein-coupled receptors (GPCRs) regulate an array of fundamental biological
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …
TYK2: an upstream kinase of STATs in cancer
K Wöss, N Simonović, B Strobl, S Macho-Maschler… - Cancers, 2019 - mdpi.com
In this review we concentrate on the recent findings describing the oncogenic potential of the
protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 …
protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 …
[HTML][HTML] Tyrosine kinase 2–Surveillant of tumours and bona fide oncogene
NR Leitner, A Witalisz-Siepracka, B Strobl, M Mueller - Cytokine, 2017 - Elsevier
Abstract Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family, which
transduces cytokine and growth factor signalling. Analysis of TYK2 loss-of-function revealed …
transduces cytokine and growth factor signalling. Analysis of TYK2 loss-of-function revealed …
Gastrin‐releasing peptide receptor (GRPr) promotes EMT, growth, and invasion in canine prostate cancer
SM Elshafae, BB Hassan, W Supsavhad… - The …, 2016 - Wiley Online Library
BACKGROUND The gastrin‐releasing peptide receptor (GRPr) is upregulated in early and
late‐stage human prostate cancer (PCa) and other solid tumors of the mammary gland, lung …
late‐stage human prostate cancer (PCa) and other solid tumors of the mammary gland, lung …
Personalization of prostate cancer therapy through phosphoproteomics
Castration-resistant prostate cancer (CRPC) remains incurable despite the approval of
several new treatments. Identification of new biomarkers and therapeutic targets to enable …
several new treatments. Identification of new biomarkers and therapeutic targets to enable …
[HTML][HTML] GRPR Drives Metastasis via CRABP2 and FNDC4 Pathways in Lung Adenocarcinoma
DG Kim, EY Choi, HM Ahn, YJ Kim - Cells, 2024 - mdpi.com
Metastasis is a leading cause of lung adenocarcinoma (LUAD)-related mortality and
presents significant challenges for treatment. The gastrin-releasing peptide receptor …
presents significant challenges for treatment. The gastrin-releasing peptide receptor …
[HTML][HTML] Oncogenic mechanisms of HOXB13 missense mutations in prostate carcinogenesis
M Cardoso, S Maia, P Paulo, MR Teixeira - Oncoscience, 2016 - ncbi.nlm.nih.gov
The recurrent germline mutation HOXB13 p.(Gly84Glu)(G84E) has recently been identified
as a risk factor for prostate cancer. In a recent study, we have performed full sequencing of …
as a risk factor for prostate cancer. In a recent study, we have performed full sequencing of …
Tyrosine phosphorylation profiling revealed the signaling network characteristics of CAMKK2 in gastric adenocarcinoma
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine
protein kinase which functions via the calcium-triggered signaling cascade with CAMK1 …
protein kinase which functions via the calcium-triggered signaling cascade with CAMK1 …
[引用][C] Pharmacological modulation of the crosstalk between aberrant Janus kinase signaling and epigenetic modifiers of the histone deacetylase family to treat cancer
AHM Mustafa, OH Krämer - Pharmacological Reviews, 2023 - ASPET
[PDF][PDF] Targeting oncogenic receptor: From molecular physiology to currently the standard of target therapy
G Zhu, AA Saboor-Yaraghi, Y Yarden - Advance Pharmaceutical …, 2017 - apjonline.in
Abstract In 1989-91, George Zhu first postulate oncogenic receptor, as a result of his
experiments in which steroid PML-RARa fusion receptor gene rearrangement within t (15; …
experiments in which steroid PML-RARa fusion receptor gene rearrangement within t (15; …