The maintenance of a healthy deoxyribonucleotide triphosphate (dNTP) pool is critical for
the proper replication and repair of both nuclear and mitochondrial DNA. Temporal, spatial …

Loss of cellular response to hormonal regulation in maintaining metabolic homeostasis is
common in the process of aging. Chronic over-nutrition may render cells insensitive to such …

Lithium orotate, the salt of lithium and orotic acid, has been marketed for decades as a
supplemental source of lithium with few recorded adverse events. Nonetheless, there have …

Chronic mountain sickness (CMS) is a high altitude complication with high rates of morbidity
and mortality. CMS is characterized by high-altitude polycythemia (HAPC) and high-altitude …

Background: Metabolic Syndrome (MetS) is a clinical diagnosis where patients exhibit three
out of the five risk factors: hypertriglyceridemia, low high-density lipoprotein (HDL) …

Studies have shown various beneficial properties of ginger to improve human health. This
study aimed to elucidate the effects of ginger on liver metabolomes and metabolic pathways …

Hypertension is a cardiovascular risk factor that has a profound influence on cardiovascular
morbidity and mortality. While good progress has been made in terms of identifying and …

Dietary administration of orotic acid (OA), an intermediate in the pyrimidine biosynthetic
pathway, is considered to provide a wide range of beneficial effects, including …

The kidney is an important target organ in the treatment of hypertension, but the effect of
peptide QIGLF with antihypertensive activity on kidneys remains unknown. In the work, we …

Here, we seek to identify metabolite predictors of dysglycemia in youth. In the discovery
analysis among 391 youth in the Exploring Perinatal Outcomes among CHildren (EPOCH) …