Drug resistance is a major challenge in cancer treatment. Emerging evidence indicates that
deregulation of YAP/TAZ signaling may be a major mechanism of intrinsic and acquired …

ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the
major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the …

The Hippo pathway is an evolutionary conserved signaling network that regulates essential
processes such as organ size, cell proliferation, migration, stemness and apoptosis …

Simple Summary Although great breakthroughs have been made in cancer treatment
following the development of targeted therapy and immune therapy, resistance against anti …

Despite advanced clinical and translational oncology research, mortality rates are still
increasing worldwide. Recently, a class of non-coding RNAs (ncRNAs), such as microRNAs …

YAP is a transcriptional co-activator with critical roles in tumorigenesis. However, its
upstream regulatory mechanism, especially how its mRNA stability is regulated, remains to …

Recent studies have suggested that Hippo signaling is not only involved in controlling organ
size in Drosophila but can also regulate cell proliferation, tissue homeostasis, differentiation …

The identification of agents that can reverse drug resistance in cancer chemotherapy, and
enhance the overall efficacy is of great interest. Paclitaxel (PTX) belongs to taxane family …

Cancer is the major cause of death worldwide in countries of all income levels. The Hippo
signaling pathway is a Drosophila kinase gene that was identified to regulate organ size …

Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC
is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs …