Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern
recognition molecule conserved in evolution which acts as a key component of humoral …

The innate immune system comprises a cellular and a humoral arm. Humoral pattern
recognition molecules include complement components, collectins, ficolins, and pentraxins …

Abstract Pentraxin-3 (PTX3) belongs to the pentraxine family, innate immune regulators
involved in angiogenesis, proliferation and immune escape in cancer. Here, we evaluated …

Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in
evolution and characterized by a cyclic multimeric structure. C-reactive protein (CRP) and …

Cutaneous melanoma is one of the most aggressive cancers characterized by a high
plasticity, a propensity for metastasis, and drug resistance. Melanomas are composed of …

Abstract Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase
protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 …

Organisms respond in multiple ways to microbial infections. Pathogen invasion tipically
triggers an inflammatory response where acute phase proteins (APP) have a key role …

Humoral fluid phase pattern recognition molecules (PRM s) are a key component of the
activation and regulation of innate immunity. Humoral PRM s are diverse. We focused on the …

Components of the cellular and the humoral arm of the immune system are essential
elements of the tumour microenvironment (TME). The TME includes tumour‐associated …

Cancer stem-like cells (CSCs) are the tumorigenic cell subpopulation and contribute to
cancer recurrence and metastasis. However, the understanding of CSC regulatory …